The Golgi Apparatus and Membrane Contact Sites

First described by electron microscopists in the early 60s the ER-Golgi contact sites in mammalian cells have remained unexplored for forty years when the discovery of lipid transfer proteins with ER and Golgi targeting motifs has provided a functional context to these structures. In the last two decades a number of proteins that have the required features to operate at the ER/Golgi contacts have been identified and the cell phenotypes deriving from their depletion described…


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